2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Bcl-xL Isoform
  6. Bcl-xL Antagonist

Bcl-xL Antagonist

Bcl-xL Antagonists (4):

Cat. No. Product Name Effect Purity
  • HY-13407
    Gossypol
    		Antagonist 99.67%
    Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
  • HY-123244
    YC137
    		Antagonist
    YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research.
  • HY-122275
    A-371191
    		Antagonist
    A-371191 is a selective Bcl-XL antagonist with a Ki <0.5 μM, and also acts as a mitochondria-targeting agent and chemosensitizer. A-371191 restores the sensitivity of cancer cells overexpressing Bcl-XL to Cisplatin (HY-17394) and Doxorubicin (HY-15142A). A-371191 reduces tumor volume in mice with intraperitoneal tumors. A-371191 can be used in the research of acute myeloid leukemia.
  • HY-P0300
    Bak BH3
    		Antagonist
    Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.